0300 A prospective follow-up study of Covid’s effects on Sleep and Cognition in post-acute period in a primarily minority population

Abstract Introduction Long Covid, the post-acute sequelae of COVID-19, has evolved in recent months into a recognized spectrum manifestations that persist after acute Covid-19 illness. Despite over 2 years information since start pandemic, data remains limited on effect Covid may have sleep and cognition. This study aims to assess association between COVID-19 infection impairment period. Methods A total 747 patients were identified from hospitalized patient records at Howard University Hospital Feb 2020 May 2021. 285 these interviewed by research team 6-12 their initial infection. Sleep symptoms collected via questionnaire 125 (64% African American, 34% Hispanic) include following four points: difficulty falling asleep, worsened quality, daytime somnolence (since occurrence) number hours 24 hours. In addition, cognitive assessment was also conducted Mini-MOCA questionnaire(n=103 patients, 59% 35% Hispanic). Of note, all participants did not report pre-COVID-19 issues concerns. We looked for any associations multiple clinical variables, disturbance, abnormal MOCA scores using proper statistical methods such as t-tests, chi-square tests, univariate multivariable logistic regression. Results Out respondents interview, 28 completing assessments declared disturbance symptoms, 79 103 Mini-Moca had an score. Patients with further analyzed significant variables: increase age (p=0.046), Diabetes Miletus diagnosis (p=0.009), elevated troponin level admission (p< 0.05), ARB use during hospitalization (p=0.006), ICU exposure ECMO (p=0.011). Not surprisingly, reduced sleeping hr period 0.0001). Conclusion Preliminary findings indicate presence longitudinal follow-up previously infected SARS-CoV-2. Additionally, we found many variables. Larger studies are required analyze associations. Support (if any)